Abstract
3H-Prazosin binding to membranes from rat brain is saturable, Bmax, 77 fmol/mg protein, of high affinity, KD, 0.28 nM and with a drug specificity indicating that it labels alpha-adrenergic receptors. The ranking of alpha-antagonists for these binding sites suggests that 3H-prazosin may be useful in identifying a subpopulation of alpha-receptors (alpha1) in the central nervous system.
MeSH terms
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Adrenergic alpha-Agonists / metabolism
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Adrenergic alpha-Antagonists / metabolism
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Animals
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Brain / metabolism*
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In Vitro Techniques
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Male
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Membranes / metabolism
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Prazosin / metabolism*
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Protein Binding
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Quinazolines / metabolism*
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Rats
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Receptors, Adrenergic / metabolism*
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Receptors, Adrenergic, alpha / metabolism*
Substances
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Adrenergic alpha-Agonists
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Adrenergic alpha-Antagonists
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Quinazolines
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Receptors, Adrenergic
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Receptors, Adrenergic, alpha
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Prazosin